Hives; This spontaneous case was reported by a consumer and describes the occurrence of URTICARIA (Hives) in an adult female patient who received mRNA-1273.815 (SPIKEVAX 2023-2024) for COVID-19 prophylaxis. Patient’s past medical history included: Hemangioma, Splenectomy, Migraines Patient’s concurrent condition included: Anaphylactic reaction due to food additives, subsequent encounter, Allergic urticaria, Allergy to milk products, Allergy to seafood, Allergy to other foods,Allergy to carrageenan, Allergy to Polysorbate 80,Hemangioma of right eyelid,Cavernoma in hypothalamus, Environmental allergies, Allergy to birch, Allergy to Timothy grass,Allergy to red Oak, Allergy to hickory,Allergy to red cedar tree, Allergy to Johnson grass, Allergy to dogs, Allergy to cats, Allergy to mice,Oral allergy syndrome,Allergy to Sulfa, Allergy to Penicillin, Headaches. Patient’s concomitant medication included: pneumonia vaccine, Meningitis vaccine, PNEUMOVAX,ZYRTEC [CETIRIZINE HYDROCHLORIDE], Allegra, Pepcid, PROPRANOLOL,TYLENOL,IBUPROFEN, Polysorbate 80. The patient’s past medical history included Hemangioma, Anaphylactic shock due to food additives, Eyelid hemangioma, Cavernoma, Headache and Splenectomy. Concurrent medical conditions included Migraine, Allergic urticaria, Seafood allergy, Environmental allergy, Oral allergy syndrome, Penicillin allergy, Allergy to plants (Allergy to red Oak), Allergy to animals (Allergy to dogs), Food allergy (Allergy to other foods), Sulfonamide allergy, Grass allergy (Allergy to Timothy grass), Drug allergy (Allergy to Polysorbate 80), Allergy to animals (Allergy to cats), Allergy to animals (Allergy to mice), Grass allergy (Allergy to Johnson grass), Allergy to plants (Allergy to birch), Allergy to plants (Allergy to red cedar tree), Allergy to plants (Allergy to hickory), Food allergy (allergic to carrageenan) and Hives. Concomitant products included CETIRIZINE HYDROCHLORIDE (ZYRTEC [CETIRIZINE HYDROCHLORIDE]), FEXOFENADINE HYDROCHLORIDE (ALLEGRA [FEXOFENADINE HYDROCHLORIDE]) and FAMOTIDINE (PEPCID [FAMOTIDINE]) for Hives, POLYSORBATE 80, Pneumococcal vaccine polysacch 23v (PNEUMOVAX), PROPRANOLOL, Paracetamol (TYLENOL) and IBUPROFEN for an unknown indication. In November 2023, the patient received dose of mRNA-1273.815 (SPIKEVAX 2023-2024) (Intramuscular use) 1 dosage form. On an unknown date, the patient experienced URTICARIA (Hives). The patient was treated with Diphenhydramine hydrochloride (Benadryl) at an unspecified dose and frequency. At the time of the report, URTICARIA (Hives) had resolved. The action taken with mRNA-1273.815 (SPIKEVAX 2023-2024) (Intramuscular use) was unknown. On -NOV-2023, patient started therapy with Moderna COVID vaccine. Patient stated that she went to get the 2023 Moderna COVID vaccine at Pharmacy and the Polysorbate 80 within the vaccine gave her hives. Patient stated that she took Benadryl, and the hives resolved about 2 days later. This case was linked to US-MODERNATX, INC.-MOD-2025-781748 (E2B Linked Report). Most recent FOLLOW-UP information incorporated above includes: On 24-Jan-2025: Live Follow-up No New Information accepted; Sender’s Comments: US-MODERNATX, INC.-MOD-2025-781748:case for everybody