diagnosed with stage four esophageal cancer; This serious case was reported by a consumer via interactive digital media and described the occurrence of esophageal cancer in a patient who received Herpes zoster (Shingles vaccine) for prophylaxis. On an unknown date, the patient received Shingles vaccine. On an unknown date, 6 months after receiving Shingles vaccine, the patient experienced esophageal cancer (Verbatim: diagnosed with stage four esophageal cancer) (serious criteria GSK medically significant). The outcome of the esophageal cancer was not reported. It was unknown if the reporter considered the esophageal cancer to be related to Shingles vaccine. The company considered the esophageal cancer to be unrelated to Shingles vaccine. Additional Information: GSK receipt date: 14-JAN-2025 This case was reported by a patient via interactive digital media. The patient reported that he/she got the shingles vaccine and six months later he/she was diagnosed with stage four esophageal cancer. The reporter mentioned that he/she could not prove any connection, but it did make them wonder.; Sender’s Comments: Oesophageal carcinoma is an unlisted event which is considered unrelated to GSK vaccine Shingles vaccine.