the syringe broke during reconstitution; This is a spontaneous report received from a Pharmacist from product quality group, Program ID. A patient (age and gender not provided) received respiratory syncytial virus vaccine prot.subunit pref 2v (ABRYSVO), as dose number unknown, single (Lot number: KC7884, Expiration Date: 30Sep2025) for immunisation, Device Lot Number: HM8389, Device Expiration Date: Sep2025. The patient’s relevant medical history and concomitant medications were not reported. The following information was reported: SYRINGE ISSUE (non-serious), outcome “unknown”, described as “the syringe broke during reconstitution”. Additional information: Pharmacist reported that they were having issues with reconstitution of respiratory syncytial virus vaccine prot.subunit pref 2v, the syringe broke during reconstitution process. Pharmacist was the one reconstituting it, had done two or three hundred of these, and this was the only one that had go wrong. The little collar on syringe broke. Pharmacist confirmed no patients were involved or administered with this vaccine. No glass shards were found. The glass vial did not break at all, only the plastic piece. Causality for “the syringe broke during reconstitution” was determined associated to device constituent of respiratory syncytial virus vaccine prot.subunit pref 2v (malfunction).