Angioedema; anaphylaxis; bumped her arm; Initial information received on 20-Jan-2025 regarding an unsolicited valid serious case received from a consumer/non-health care professional. This case involves a 70 years old female patient who had angioedema, anaphylaxis and bumped her arm after receiving Influenza Quadrival A-B High Dose Hv Vaccine [Fluzone High-Dose Quadrivalent]. The patient’s past medical history, medical treatment(s), vaccination(s), concomitant medications and family history were not provided. Ona n unknown date in November 2024, the patient received a unknown dose of suspect Influenza Quadrival A-B High Dose Hv Vaccine lot U8161CA via intramuscular route in the left arm for Immunization (strength, formulation, expiry date was unknown). On an unknown date the patient developed angioedema, anaphylaxis (anaphylactic reaction) and bumped her arm (peripheral swelling) (unknown latency) following the administration of Influenza Quadrival A-B High Dose Hv Vaccine. Reportedly “She is not sure if she got the flu vaccine at that location in the past. .” Action taken was not applicable for all the events. It was not reported if the patient received a corrective treatment for the events (Angioedema, bumped her arm, anaphylaxis). At time of reporting, the outcome was Unknown for the events. Seriousness Criteria : Medically significant for the events angioedema and anaphylactic reaction.; Sender’s Comments: Sanofi Company Comment dated 23-Jan-2025 : This case involves a 70-year-old female patient who had angioedema, anaphylaxis after receiving Influenza Quadrival A-B High Dose Hv Vaccine [Fluzone High-Dose Quadrivalent].Further information regarding Past medical history, concurrent condition, concomitant medication and tolerance, allergic history, laboratory investigations excluding alternative etiologies for the reported events are needed to fully assess this case. Based upon the reported information, the role of a vaccine cannot be assessed.