COVID-19; COVID-19; This is a spontaneous report received from a Physician. A 76-year-old female patient received BNT162b2 omi xbb.1.5 (COMIRNATY (2023-2024 FORMULA)), on 03Jul2024 as dose 1, single (Batch/Lot number: unknown) at the age of 75 years for covid-19 immunisation. The patient’s relevant medical history included: “aortic dissection”, start date: 23Dec2015 (unspecified if ongoing), notes: was medical emergency, genetic, probably thirty people in family would have had it, is a disabling feature of patient; “memory issues”, start date: Mar2016 (unspecified if ongoing), notes: became more progressive, right now patient is stable; “head scan”, start date: Sep2015 (unspecified if ongoing), notes: helped with diagnosis of memory issues. There were no concomitant medications. Vaccination history included: Moderna covid-19 vaccine (DOSE 1), for Covid-19 immunization; Moderna covid-19 vaccine (DOSE 2), for Covid-19 immunization; Moderna covid-19 vaccine (DOSE 3 (BOOSTER)), for Covid-19 immunization; Moderna covid-19 vaccine (DOSE 4 (BOOSTER)), for Covid-19 immunization; Moderna bvln bstr (DOSE 5 (BOOSTER)), for Covid-19 immunization; Spikevax 12 plus (DOSE 6 (BOOSTER)), for Covid-19 immunization. The following information was reported: VACCINATION FAILURE (hospitalization, medically significant), COVID-19 (hospitalization, medically significant), outcome “unknown” and all described as “COVID-19”. The clinical course was reported as follows: It was reported that the patient had gotten COVID three times, and twice patient had to be hospitalized, confirmed admitted into hospital, either for two nights or for four nights. Third time patient had to be in the emergency room about seven hours, and then patient seemed fine. The reporter could take patient home or leave her there, thought with patient’s memory issues, the patient was probably better at home, but he stated should had left her there. Whenever patient got, was more problematic than when other people were getting it, so had gone ahead and given patient next booster. The patient’s husband thought patient had had eight doses now (got other dose in either Sep2024 or Oct2024). The patient shifted over to Pfizer because patient’s first doses were Moderna. The patient got Comirnaty 12 plus on 03Jul2024, the reporter thought the dose patient got of Comirnaty 12 plus must have been Pfizer, but unable to confirm.; Sender’s Comments: A causal relationship to the suspect drug BNT162B2 OMI XBB.1.5 cannot be excluded for event vaccination failure. This case will be reassessed upon receipt of additional information.