Suspected vaccination failure; Shingles again in 2020; I have been diagnosed with Shingles yesterday; This serious case was reported by a consumer via sales rep and described the occurrence of vaccination failure in a 63-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis. The patient’s past medical history included shingles. On an unknown date, the patient received Shingrix. On 01-JAN-2025, more than 2 years after receiving Shingrix, the patient experienced shingles (Verbatim: I have been diagnosed with Shingles yesterday). On an unknown date, the patient experienced vaccination failure (Verbatim: Suspected vaccination failure) (serious criteria GSK medically significant) and shingles (Verbatim: Shingles again in 2020). The outcome of the vaccination failure and shingles were not reported and the outcome of the shingles was resolving. It was unknown if the reporter considered the vaccination failure, shingles and shingles to be related to Shingrix. The company considered the vaccination failure to be unrelated to Shingrix. It was unknown if the company considered the shingles and shingles to be related to Shingrix. Additional Information: GSK Receipt Date: 12-JAN-2025 The patient had received Shingrix vaccine in 2017. She had been diagnosed with Shingles the day before reporting. She had Shingles again in 2020 as well. The patient enquired if the drug was not effective for some people. The patient wonder if there is a booster that would be effective. The patient symptoms were treated. This case was considered as suspected vaccination failure as details regarding completion of primary vaccination schedule and laboratory confirmation regarding shingles were unknown at the time of reporting.; Sender’s Comments: Vaccination failure is a listed event which, due to the following criteria (insufficient information provided about the completion of primary vaccination schedule and laboratory confirmation of disease) is considered unrelated to GSK vaccine Shingrix.