intermittent muscle pains /leg muscle pain; weakness in legs; difficult to climb stairs/rise from sitting position; No longer have muscle pains in arms and body; This non-serious case was reported by a consumer and described the occurrence of myalgia of lower extremities in a 87-year-old female patient who received RSVPreF3 adjuvanted (Arexvy) for prophylaxis. Concurrent medical conditions included hypertension (Treated with Ramipril and Carvedilol), transient ischemic attack (Patient had Transient ischaemic attack in 1999), blood cholesterol increased (Treated with Crestor) and cardiovascular risk (Treated with Jardiance). Concomitant products included carvedilol, ramipril, clopidogrel bisulfate (Plavix), rosuvastatin calcium (Crestor) and empagliflozin (Jardiance). On 23-OCT-2024, the patient received Arexvy. On 28-OCT-2024, 5 days after receiving Arexvy, the patient experienced myalgia of lower extremities (Verbatim: intermittent muscle pains /leg muscle pain), lower extremities weakness of (Verbatim: weakness in legs), activities of daily living impaired (Verbatim: difficult to climb stairs/rise from sitting position) and generalized muscle aches (Verbatim: No longer have muscle pains in arms and body). The outcome of the myalgia of lower extremities, lower extremities weakness of and activities of daily living impaired were not resolved and the outcome of the generalized muscle aches was resolved. It was unknown if the reporter considered the myalgia of lower extremities, lower extremities weakness of, activities of daily living impaired and generalized muscle aches to be related to Arexvy. It was unknown if the company considered the myalgia of lower extremities, lower extremities weakness of, activities of daily living impaired and generalized muscle aches to be related to Arexvy. Additional Information: GSK Receipt Date: 27-DEC-2024 A 87 year female patient received Arexvy vaccine and experienced intermittent muscle pain and weakness in leg. The patient no longer had muscle pains in arms and body but leg pains still persist which was severe at time, worse at night. Leg weakness still persists making it difficult to climb stairs and rise from sitting position. The patient reported that the symptoms was not treated. The patient current condition includes hypertension, Transient ischaemic attack, High cholesterol and Cardiovascular risk