fever/ started fever within one hour and could not break it; This spontaneous case was reported by an other health care professional and describes the occurrence of PYREXIA (fever/ started fever within one hour and could not break it) in a female patient of an unknown age who received SPIKEVAX NOS (SPIKEVAX NOS) for COVID-19 prophylaxis. No Medical History information was reported. On an unknown date, the patient received dose of SPIKEVAX NOS (SPIKEVAX NOS) (Intramuscular use) 1 dosage form. On an unknown date, the patient experienced PYREXIA (fever/ started fever within one hour and could not break it) (seriousness criterion medically significant). At the time of the report, PYREXIA (fever/ started fever within one hour and could not break it) had not resolved. The action taken with SPIKEVAX NOS (SPIKEVAX NOS) (Intramuscular use) was unknown. For SPIKEVAX NOS (SPIKEVAX NOS) (Intramuscular use), the reporter did not provide any causality assessments. No concomitant medication was reported. The patient had no medical history, concomitant disease or risk factor. Reporter causality was not reported. The patient did not experience any additional symptoms or events. There were no lab data or results available. No treatment information was provided. Most recent FOLLOW-UP information incorporated above includes: On 16-Jan-2025: Live significant follow-up information received contains reporter’s state, event verbatim and event seriousness criteria added as medically significant, and additional references were added.; Reporter’s Comments: The benefit-risk relationship of product is not affected by this report.