Autoimmune disorder; Case reference number US-BN-2025-000136 is a spontaneous case initially received from consumer via Communication (reference number: USBAV25-0136) on 17-Jan-2025 and concerns a male patient of unspecified age. The patient’s medical history and concomitant medication details were not provided. On an unspecified date in Sep-2022, the patient received the first dose of Jynneos vaccine (batch number: unknown), at unknown dose, route or site of administration for unknown indication. On an unspecified date in Oct-2022, for unknown of time from the first dose, the patient received the second dose of Jynneos vaccine (batch number: unknown), at unknown dose, route or site of administration. On an unspecified date, unknown of time after vaccination with Jynneos, reported as in the last 24 hours, the patient got diagnosed with autoimmune disorder. At the time of initial report, it was unknown if the patient recovered from the event of autoimmune disorder. The reporter assessed the event of autoimmune disorder as serious due to criteria of disability and medical significance and possible related to Jynneos. No further information was provided.; Reporter’s Comments: A male patient received two doses of the Jynneos vaccine in Sep and Oct 2022. Recently, he was diagnosed with an autoimmune disorder. Recovery status is unknown. The patient’s medical history and concomitant medication details were not provided. The reported event autoimmune disorder is considered unlisted as per RA v7.0 and RA. The causality is assessed as related due to lack of alternative explanation at this point, and since contributory role of suspect product cannot be excluded. The case is serious due to disability and medical significance.; Sender’s Comments: A male patient received two doses of the Jynneos vaccine in Sep and Oct 2022. Recently, he was diagnosed with an autoimmune disorder. Recovery status is unknown. The patient’s medical history and concomitant medication details were not provided. The reported event autoimmune disorder is considered unlisted as per RA v7.0 and RA. The causality was assessed as related due to lack of alternative explanation at this point, and since contributory role of suspect product and a plausible mechanism of action cannot be excluded. The case is serious due to disability and medical significance.