Patient called clinic approximately 15-20 minutes after receiving vaccination, reporting significant full body itching, hand erythema, and itching on tongue. At time of call with RN did not have further symptoms. Was advised to take PO benadryl immediately, monitor for worsening symptoms and if so call 911. Later received update that patient reported shortness of breath, facial swelling, and tingling, but airway intact. 50mg IV benadryl given by EMS prior to arrival to local ER. Currently in ER for monitoring.