vaccine leak; Product Complaint; While trying to remove bubble in pre-filled syringe, the vaccine leaked onto the nurse’s ungloved hand; This non-serious case was reported by a nurse via call center representative and described the occurrence of occupational exposure via skin contact with product in a female patient who received Men B NVS (Bexsero) (batch number 77KA5, expiry date 30-NOV-2027) for prophylaxis. This case was associated with a product complaint. On an unknown date, the patient received Bexsero. On 02-DEC-2024, an unknown time after receiving Bexsero, the patient experienced occupational exposure via skin contact with product (Verbatim: While trying to remove bubble in pre-filled syringe, the vaccine leaked onto the nurse’s ungloved hand). On an unknown date, the patient experienced product leakage (Verbatim: vaccine leak) and pharmaceutical product complaint (Verbatim: Product Complaint). The outcome of the occupational exposure via skin contact with product, product leakage and pharmaceutical product complaint were unknown. This report is made by GSK without prejudice and does not imply any admission or liability for the incident or its consequences. Additional Information: GSK Receipt Date: 02-DEC-2024 The reporter stated that seven Bexsero pre-filled syringes each contained a large (full width of the syringe, about half the volume of vaccine), clear, air bubble that was observed during preparation for administration and was unable to be remove without wasting vaccine. While trying to remove bubble during this phone call, the vaccine leaked onto the nurse’s ungloved hand which led to occupational exposure via skin contact with product. Confirmed that all operations were performed appropriately before the defect was discovered. The product was not administered. There were not any visible damage present on the syringe. There were not any temperature excursions during storage. The product was at room temperature when particle was observed. Requested return of the suspect pre-filled syringes and all the original packaging without further manipulation/handling.