suspected vaccination failure; Shingles; Colonoscopy; This serious case was reported by a consumer via call center representative and described the occurrence of vaccination failure in a 74-year-old male patient who received Herpes zoster (Shingrix) for prophylaxis. Co-suspect products included Herpes zoster (Shingrix) for prophylaxis. On an unknown date, the patient received the 2nd dose of Shingrix (unknown arm). In DEC-2020, the patient received the 1st dose of Shingrix (unknown arm). On an unknown date, an unknown time after receiving Shingrix and Shingrix, the patient experienced vaccination failure (Verbatim: suspected vaccination failure) (serious criteria GSK medically significant), shingles (Verbatim: Shingles) and colonoscopy (Verbatim: Colonoscopy). The outcome of the vaccination failure and colonoscopy were not reported and the outcome of the shingles was not resolved. It was unknown if the reporter considered the vaccination failure, shingles and colonoscopy to be related to Shingrix and Shingrix. The company considered the vaccination failure to be unrelated to Shingrix and Shingrix. It was unknown if the company considered the shingles and colonoscopy to be related to Shingrix and Shingrix. Additional Information: GSK Receipt Date: 16-DEC-2024 The patient did not report the location where the vaccine was provided. It was unknown in which arm the vaccines were administered. The patient reported that he got the first dose of Shingrix and received the second dose in April or May of 2021 and had an episode of Shingles after receiving these two doses. The patient did not provide the date of the episodes. The patient reported that recently he got a colonoscopy, and about a week after he had the second episode of shingles and the liquid was provided for the colonoscopy process was a clear cranberry liquid with high concentrations of sugar. The patient reported that he searched and found that high amounts of sugar can trigger shingles. The patient reported that in his case, the shingles have been triggered by the anesthesia and the high concentrations of sugar given during the colonoscopy procedure. The patient reported that he still has shingles, and it has not resolved. The patient inquired that it was recommended to get another series of the vaccine. Not all information was available. Adverse event would be filed with limited information. The patient declined to provide additional information. This case was considered as suspected vaccination failure as details regarding time to onset for shingles and laboratory confirmation regarding shingles were unknown at the time of reporting.; Sender’s Comments: Vaccination failure is a listed event which, due to the following criteria (insufficient information provided about the clinical description, time to onset and laboratory confirmation of disease) is considered unrelated to GSK vaccine Shingrix (dose 1) and Shingrix (dose 2).